A thermodynamic framework for unified continuum models for the healing of damaged soft biological tissue

When they are damaged or injured, soft biological tissues able to self-repair and heal. Mechanics is critical during the healing process, as extracellular matrix (ECM) tends be replaced with a new undamaged ECM supporting homeostatic stresses. Computational modeling has been commonly used simulate process. However, there pressing need have unified thermodynamics theory for healing. From viewpoint of continuum damage mechanics, some key parameters related processes, instance, volume fraction newly grown tissue growth deformation, can regarded internal variables evolution equations. This paper aiming establish this framework inspired by models tissues. The significant advantage proposed model that no \textit{ad hoc} equations required describing Therefore, more concise offers universal approach Three numerical examples provided demonstrate effectiveness model, which in good agreement existing works, including an application balloon angioplasty arteriosclerotic artery fiber cap.